William G Whitford
GE Health Care, USA
Title: Materials design enabling upstream continuous biomanufacturing
Biography
Biography: William G Whitford
Abstract
Upstream continuous biomanufacturing is supported by a number of new approaches to perfusion culture. This includes continuing developments in single-use systems and cell-culture media design. SU perfusion-capable systems support a high degree of flexibility in process flow and configuration, component types, physical location and production mode. Continuous biomanufacturing through bioproduction in a high-cell density perfusion culture is an exciting potential. Data from a structured approach to developing a perfusion medium from a combination of commercially available medium and feeds will be presented. Insights as to how this methodology can be applied to other cell culture media will be outlined. Optimization of culture media and process fluids for such intensified processes also includes such new ideas as heightened process understanding, the relative value of powder vs. bulk liquid and in-line fluids conditioning. Employment of such is enabled by higher specific productivities, regional manufacturing and improved shipping/packaging technologies. These activities support the ultimate goal of real-time, continuous quality and process verification in pre-engineered, modular multi-product manufacturing facilities.
