Ali Jazayeri
Heptares Therapeutics, UK
Title: Using StaR Proteins as Antigens to Generate Antibodies to GPCRs
Biography
Biography: Ali Jazayeri
Abstract
GPCRs represent excellent antibody targets given their central role in the pathology of many diseases and cell surface location. However GPCRs make poor antigens due to their conformational flexibility, low expression levels, inherent instability and hydrophobic nature. Using protein engineering approaches we create conformationally stabilised receptors (StaRs) that can be purified to high purity and homogeneity with enhanced half-life. StaRs allow generation of high quality antigens that can be used to raise functional antibodies.
